HCID 69780447, Verbindung → HCID 86587005, Verbindung

HRID 1266848Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1266848
C(O[C:4]([C:6]1[N:7]=[CH:8][O:9][C:10]=1[C:11]1[CH:16]=[CH:15][CH:14]=[C:13]([C:17]2[CH2:18][C:19](=[O:33])[NH:20][C:21]3[CH:27]=[C:26]([N:28]4[CH:32]=[CH:31][CH:30]=[CH:29]4)[CH:25]=[CH:24][C:22]=3[N:23]=2)[CH:12]=1)=[O:5])C>NCCO>[OH:5][CH2:4][CH2:6][NH:7][C:4]([C:6]1[N:7]=[CH:8][O:9][C:10]=1[C:11]1[CH:16]=[CH:15][CH:14]=[C:13]([C:17]2[CH2:18][C:19](=[O:33])[NH:20][C:21]3[CH:27]=[C:26]([N:28]4[CH:32]=[CH:31][CH:30]=[CH:29]4)[CH:25]=[CH:24][C:22]=3[N:23]=2)[CH:12]=1)=[O:5]

Komponenten

3

Edukt 1

HCID 69780447HCID 69780447, Verbindung

Produkt 1

HCID 86587005HCID 86587005, VerbindungAusbeute 110,5 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 700EthanolamineLösungsmittel

Versuchsvorschrift

A solution of 5-[3-(4-oxo-7-pyrrol-1-yl-4,5-dihydro-3H-benzo[b][1,4]diazepin-2-yl)-phenyl]-oxazole-4-carboxylic acid ethyl ester (Example 23) (35mg) in 2-amino-ethanol (1 mL) was stirred at 50° C. for 4 h. The mixture was partitioned between H2O and EtOAc. The organic layer was dried and evaporated in vacuum, and the residue was triturated with EtOAc to give the title compound (20 mg) as light-yellow solid.

Aufarbeitung

  1. customThe mixture was partitioned between H2O and EtOAc
  2. customThe organic layer was dried
  3. customevaporated in vacuum
  4. customthe residue was triturated with EtOAc

Quellen und Nachweise

ORD-Eintrag
ord-4d3393e9a666440b84cd00455139561c
Quelldatensatz
uspto-grants-2003_04
Patentnummer
US06548495B2

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