HuagongsheHuagongshe Chemie-Druckbericht · Nur für Forschungszwecke
Diethyl Malonate → 4-(6-Acetylaminoindan-1-yl)butanoic acid
Beteiligte Stoffe
| Rolle | Name | HCID | Einwaage |
|---|---|---|---|
| Edukt | Diethyl Malonate | HCID 7761 | — |
| Edukt | Potassium Cyanide | HCID 9032 | — |
| Edukt | Indane | HCID 10326 | — |
| Edukt | 6-Nitro-2,3-dihydro-1H-indene-1-carboxylic acid | HCID 12318488 | — |
| Produkt | 4-(6-Acetylaminoindan-1-yl)butanoic acid | HCID 18545843 | — |
| Produkt | 2-(6-Acetylaminoindan-1-yl)acetic acid | HCID 18545899 | — |
| Produkt | 3-(6-Acetylaminoindan-1-yl)propanoic acid | HCID 18545930 | — |
Reaktionsschritte
2-(6-acetylaminoindan-1-yl)acetic acid, 3-(6-acetylaminoindan-1-yl)propanoic acid and 4-(6-acetylaminoindan-1-yl)butanoic acid were prepared from 6-nitro-1-indanecarboxylic acid by classical chain elongations by using KCN or diethyl malonate. The methodology is described for an analogous indane serie by R. Gruber et al. Tetrahedron 1974, 30, 3605-10. Alane was used for the reduction of the intermediate carboxylic acids.
Herkunft & Nachweise
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patentnummer | US06552044B2 |
| Quelldatensatz | uspto-grants-2003_04 |
| ORD ID | ord-edf5d2dd411a45418a1a807bd77dd981 |
| Quellennotiz | uspto-grants-2003_04 |