Ethylene Glycol → 2-(8-Hydroxy-7-oxo-octyl)cyclopent-2-en-1-one-7-ethylene ketal

HRID 126736Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 126736
[OH:1][CH2:2][C:3](=[O:16])[CH2:4][CH2:5][CH2:6][CH2:7][CH2:8][CH2:9][C:10]1[C:11](=[O:15])[CH2:12][CH2:13][CH:14]=1.[CH2:17](O)[CH2:18][OH:19].CC1C=CC(S(O)(=O)=O)=CC=1.C(=O)(O)[O-].[Na+]>C1(C)C=CC=CC=1>[CH2:18]1[O:19][C:11]2([CH2:12][CH2:13][CH:14]=[C:10]2[CH2:9][CH2:8][CH2:7][CH2:6][CH2:5][CH2:4][C:3](=[O:16])[CH2:2][OH:1])[O:15][CH2:17]1

Komponenten

6

Edukt 4

HCID 174Ethylene GlycolHCID 6101p-Toluenesulfonic acidHCID 516892Sodium BicarbonateHCID 202876282-(8-Hydroxy-7-oxo-octyl)cyclopent-2-en-1-one

Produkt 1

HCID 867375372-(8-Hydroxy-7-oxo-octyl)cyclopent-2-en-1-one-7-ethylene ketal

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 1140TolueneLösungsmittel

Versuchsvorschrift

A solution of 5.5 g. of 2-(8-hydroxy-7-oxo-octyl)cyclopent-2-en-1-one (Example 88), 25 ml. of ethylene glycol, and 0.1 g. of P-toluenesulfonic acid in 200 ml. of toluene is reflucted for 40 minutes using a Dean-Stark trap. The solution is poured into saturated sodium bicarbonate. The mixture is extracted with benzene. The organic solution is washed three times with water and dried over magnesium sulfate. The solvent is removed to give 6.0 g. of the title compound.

Aufarbeitung

  1. extractionThe mixture is extracted with benzene
  2. washThe organic solution is washed three times with water
  3. dry with materialdried over magnesium sulfate
  4. customThe solvent is removed
  5. customto give 6.0 g

Quellen und Nachweise

ORD-Eintrag
ord-f49fcb853420467cba341134c29cc80e
Quelldatensatz
uspto-grants-1981_03
Patentnummer
US04254036

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