Diethyl Malonate → 11-[(3RS,4RS)-3-ethyl-7-hydroxy-3-(4-hydroxyphenyl)thiochroman-4-yl]-2-(3,3,4,4,5,5,6,6,6-nonafluorohexyl)undecanoic acid

Reaktionsgleichung

[F:1][C:2]([F:29])([C:19]([F:28])([F:27])[C:20]([F:26])([F:25])[C:21]([F:24])([F:23])[F:22])[CH2:3][CH2:4][CH:5]([CH2:11][CH2:12][CH2:13][CH2:14][CH2:15][CH2:16][CH:17]=[CH2:18])[C:6]([O:8]CC)=[O:7].C(OCC)(=O)CC(OCC)=O.BrCCCCCCC=C.ICCC(F)(F)C(F)(F)C(F)(F)C(F)(F)F.[CH2:66]([C:68]1([C:104]2[CH:109]=[CH:108][C:107]([OH:110])=[CH:106][CH:105]=2)[CH:77]([CH2:78]CCCCCCCC(CCCCCCC(F)(F)C(F)(F)F)C(O)=O)[C:76]2[C:71](=[CH:72][C:73]([OH:103])=[CH:74][CH:75]=2)[S:70][CH2:69]1)[CH3:67]>>[CH2:66]([C:68]1([C:104]2[CH:105]=[CH:106][C:107]([OH:110])=[CH:108][CH:109]=2)[CH:77]([CH2:78][CH2:18][CH2:17][CH2:16][CH2:15][CH2:14][CH2:13][CH2:12][CH2:11][CH:5]([CH2:4][CH2:3][C:2]([F:29])([F:1])[C:19]([F:27])([F:28])[C:20]([F:25])([F:26])[C:21]([F:24])([F:22])[F:23])[C:6]([OH:8])=[O:7])[C:76]2[C:71](=[CH:72][C:73]([OH:103])=[CH:74][CH:75]=2)[S:70][CH2:69]1)[CH3:67]