10-[(3RS,4RS)-7-hydroxy-3-(4-hydroxyphenyl)-3-propylthiochroman-4-yl]-2-(4,4,5,5,5-pentafluoropentyl)decanoic acid → 11-[(3Rs,4rs)-7-hydroxy-3-(4-hydroxyphenyl)-3-propylthiochroman-4-yl]-2-(4,4,5,5,5,-pentafluoropentyl)undecanoic acid

HRID 1267788Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1267788
[OH:1][C:2]1[CH:11]=[C:10]2[C:5]([CH:6]([CH2:22]CCCCCCCC(CCCC(F)(F)C(F)(F)F)C(O)=O)[C:7]([C:15]3[CH:20]=[CH:19][C:18]([OH:21])=[CH:17][CH:16]=3)([CH2:12][CH2:13][CH3:14])[CH2:8][S:9]2)=[CH:4][CH:3]=1.[F:44][C:45]([F:67])([C:63]([F:66])([F:65])[F:64])[CH2:46][CH2:47][CH2:48][CH:49]([CH2:55][CH2:56][CH2:57][CH2:58][CH2:59][CH2:60][CH:61]=[CH2:62])[C:50]([O:52]CC)=[O:51]>>[OH:1][C:2]1[CH:11]=[C:10]2[C:5]([CH:6]([CH2:22][CH2:62][CH2:61][CH2:60][CH2:59][CH2:58][CH2:57][CH2:56][CH2:55][CH:49]([CH2:48][CH2:47][CH2:46][C:45]([F:44])([F:67])[C:63]([F:64])([F:65])[F:66])[C:50]([OH:52])=[O:51])[C:7]([C:15]3[CH:16]=[CH:17][C:18]([OH:21])=[CH:19][CH:20]=3)([CH2:12][CH2:13][CH3:14])[CH2:8][S:9]2)=[CH:4][CH:3]=1

Komponenten

3

Edukt 2

HCID 1021140610-[(3RS,4RS)-7-hydroxy-3-(4-hydroxyphenyl)-3-propylthiochroman-4-yl]-2-(4,4,5,5,5-pentafluoropentyl)decanoic acidHCID 12043786Ethyl 2-(4,4,5,5,5-pentafluoropentyl)-9-decenoate

Produkt 1

HCID 1028299511-[(3Rs,4rs)-7-hydroxy-3-(4-hydroxyphenyl)-3-propylthiochroman-4-yl]-2-(4,4,5,5,5,-pentafluoropentyl)undecanoic acid

Versuchsvorschrift

Starting with the allyl compound prepared in Example 29 and ethyl 2-(4,4,5,5,5,-pentafluoropentyl)-9-decenoate prepared separately, the same procedure as shown in Example 13 was repeated to give 11-[(3RS,4RS)-7-hydroxy-3-(4-hydroxyphenyl)-3-propylthiochroman-4-yl]-2-(4,4,5,5,5,-pentafluoropentyl)undecanoic acid.

Aufarbeitung

  1. customprepared separately

Quellen und Nachweise

ORD-Eintrag
ord-3e7ff9321b834cf687237312c1e5f3f0
Quelldatensatz
uspto-grants-2003_04
Patentnummer
US06552068B1

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