3-Benzoyl-1-(4-chloro-butyl)-5-(2-methyl-pyridin-4-yl)-1H-pyrimidine-2,4-dione → 1-(4-Chloro-butyl)-5-(2-methyl-pyridin-4-yl)-1H-pyrimidine-2,4-dione

HRID 12678

Reaktionsgleichung

Reaktionsgleichung von HRID 12678
C([N:9]1[C:14](=[O:15])[C:13]([C:16]2[CH:21]=[CH:20][N:19]=[C:18]([CH3:22])[CH:17]=2)=[CH:12][N:11]([CH2:23][CH2:24][CH2:25][CH2:26][Cl:27])[C:10]1=[O:28])(=O)C1C=CC=CC=1>N.CO>[Cl:27][CH2:26][CH2:25][CH2:24][CH2:23][N:11]1[CH:12]=[C:13]([C:16]2[CH:21]=[CH:20][N:19]=[C:18]([CH3:22])[CH:17]=2)[C:14](=[O:15])[NH:9][C:10]1=[O:28]

Komponenten

4

Edukt 1

HCID 589941843-Benzoyl-1-(4-chloro-butyl)-5-(2-methyl-pyridin-4-yl)-1H-pyrimidine-2,4-dione

Produkt 1

HCID 589941791-(4-Chloro-butyl)-5-(2-methyl-pyridin-4-yl)-1H-pyrimidine-2,4-dione

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 222AmmoniaLösungsmittelHCID 887MethanolLösungsmittel

Versuchsvorschrift

3-Benzoyl-1-(4-chloro-butyl)-5-(2-methyl-pyridin-4-yl)-1H-pyrimidine-2,4-dione (Prep 45, 100 mg, 0.25 mmol) was dissolved in a solution of 3% NH3 in MeOH (5 mL). The mixture was stirred at room temperature for 3 hours, the solvent was then evaporated under vacuum to give the title compound that was used in the next step without further purification.

Aufarbeitung

  1. customthe solvent was then evaporated under vacuum

Quellen und Nachweise

ORD-Eintrag
ord-67e7e7cac166413a9063e2eaf416ec76
Quelldatensatz
uspto-grants-2010_06
Patentnummer
US07727988B2

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