Sodium Hydroxide → (1-Acetylpiperidin-4-yl)acetic acid

HRID 126857Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 126857
[C:1]([N:4]1[CH2:9][CH2:8][CH:7]([CH2:10][C:11]([O:13]CC)=[O:12])[CH2:6][CH2:5]1)(=[O:3])[CH3:2].[OH-].[Na+]>C(O)C>[C:1]([N:4]1[CH2:9][CH2:8][CH:7]([CH2:10][C:11]([OH:13])=[O:12])[CH2:6][CH2:5]1)(=[O:3])[CH3:2]

Komponenten

4

Edukt 2

HCID 14798Sodium HydroxideHCID 54363171Ethyl 1-acetyl-4-piperidineacetate

Produkt 1

HCID 10442408(1-Acetylpiperidin-4-yl)acetic acidAusbeute 36,5 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 702EthanolLösungsmittel

Versuchsvorschrift

To a stirred solution of 92 parts of ethyl 1-acetyl-4-piperidineacetate in 200 parts of ethanol are added dropwise (slowly) 65 parts of sodium hydroxide solution 30%. Upon completion, stirring is continued for 2 hours in a warm water-bath. The reaction mixture is poured onto water and the whole is filtered over hyflo. The clear filtrate is concentrated to a third of its volume and the concentrate is acidified with a diluted hydrochloric acid solution. While cooling, the product is allowed to crystallize. It is filtered off and dried, yielding 29 parts (36.5%) of 1-acetyl-4-piperidineacetic acid; mp. 124.1° C.

Aufarbeitung

  1. additionThe reaction mixture is poured onto water
  2. filtrationthe whole is filtered over hyflo
  3. concentrationThe clear filtrate is concentrated to a third of its volume
  4. temperatureWhile cooling
  5. customto crystallize
  6. filtrationIt is filtered off
  7. customdried

Quellen und Nachweise

ORD-Eintrag
ord-d56d45b94ed74a0d8f100f148fb2db11
Quelldatensatz
uspto-grants-1981_03
Patentnummer
US04254127

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