Thionyl Chloride → 1-Acetyl-4-piperidineacetyl chloride

HRID 126858Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 126858
S(Cl)([Cl:3])=O.[C:5]([N:8]1[CH2:13][CH2:12][CH:11]([CH2:14][C:15]([OH:17])=O)[CH2:10][CH2:9]1)(=[O:7])[CH3:6]>>[C:5]([N:8]1[CH2:13][CH2:12][CH:11]([CH2:14][C:15]([Cl:3])=[O:17])[CH2:10][CH2:9]1)(=[O:7])[CH3:6]

Komponenten

3

Edukt 2

HCID 24386Thionyl ChlorideHCID 10442408(1-Acetylpiperidin-4-yl)acetic acid

Produkt 1

HCID 202880651-Acetyl-4-piperidineacetyl chlorideAusbeute 95 %

Versuchsvorschrift

To 240 parts of thionyl chloride are added portionwise 25 parts of 1-acetyl-4-piperidineacetic acid and the whole is stirred overnight at room temperature. The reaction mixture is evaporated, yielding 26.5 parts (95%) of 1-acetyl-4-piperidineacetyl chloride as an oily residue.

Aufarbeitung

  1. customThe reaction mixture is evaporated

Quellen und Nachweise

ORD-Eintrag
ord-6d0ab50928a64ba0a9220c1c4b1ab58e
Quelldatensatz
uspto-grants-1981_03
Patentnummer
US04254127

Notizen zur Reaktion

Wird geladen…