1,4-Dioxane → 1,2,3,4-Tetrahydro-2,4-dioxo-1-(4-oxobutyl)-5-pyrimidinecarbonitrile

HRID 12686Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 12686
C(O[C:4](OCC)([CH3:17])[CH2:5][CH2:6][N:7]1[CH:12]=[C:11]([C:13]#[N:14])[C:10](=[O:15])[NH:9][C:8]1=[O:16])C.[O:21]1CCOCC1>>[O:16]=[C:8]1[NH:9][C:10](=[O:15])[C:11]([C:13]#[N:14])=[CH:12][N:7]1[CH2:6][CH2:5][CH2:4][CH:17]=[O:21]

Komponenten

3

Edukt 2

HCID 312751,4-DioxaneHCID 686958921-(3,3-Diethoxy-butyl)-2,4-dioxo-1,2,3,4-tetrahydro-pyrimidine-5-carbonitrile

Produkt 1

HCID 589942301,2,3,4-Tetrahydro-2,4-dioxo-1-(4-oxobutyl)-5-pyrimidinecarbonitrile

Reaktionsbedingungen

Temperatur
60 °C

Versuchsvorschrift

1-(3,3-Diethoxy-butyl)-2,4-dioxo-1,2,3,4-tetrahydro-pyrimidine-5-carbonitrile (Prep 54, 200 mg, 0.71 mmol) was dissolved in dioxane (8 mL) and 1N HClaq (1 mL) was added. The mixture was warmed at 60° C. for 20 minutes. The solvents were evaporated, the residue was submitted to lyophilization, to give 150 mg of the title compound that was used in the next step without further purification (quantitative yield).

Aufarbeitung

  1. addition1N HClaq (1 mL) was added
  2. customThe solvents were evaporated

Quellen und Nachweise

ORD-Eintrag
ord-aed69bfe41c4432fba303d31b332e3f4
Quelldatensatz
uspto-grants-2010_06
Patentnummer
US07727988B2

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