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HuagongsheHuagongshe Chemie-Druckbericht · Nur für Forschungszwecke
HRID 1268681Erstellt: 26. Oktober 2026

2-Amino-4-methylpyridine → 2-(4'-Chloropropoxy-3'-methoxyphenyl)-7-methylimidazo[1,2-a]pyridine hydrobromide

https://huagongshe.com/reaction/1268681

Reaktionsgleichung

Beteiligte Stoffe

RolleNameHCIDEinwaage
Edukt2-Amino-4-methylpyridineHCID 1533—
Eduktalpha-Bromo-3'-methoxy-4'-chloropropoxyacetophenoneHCID 22015629—
LösungsmittelEthanolHCID 702—
Produkt2-(4'-Chloropropoxy-3'-methoxyphenyl)-7-methylimidazo[1,2-a]pyridine hydrobromideHCID 2201559870,5%

Reaktionsschritte

A solution of the product of Step B (1.44 g) and 2-amino-4-picoline (0.486 g) in ethanol (6 mL) was heated at 730 C for 1 hour. The reaction mixture was cooled to ambient temperature and evaporated to a yellow solid. The solid was stirred with 25 mL of dichloromethane for approximately 10 minutes. The mixture was filtered and the solid product collected to yield the title compound (1.3 g).

Herkunft & Nachweise

DOI10.6084/m9.figshare.5104873.v1
PatentnummerUS07199117B2
Quelldatensatzuspto-grants-2007_04
ORD IDord-182ef95a5673486687b03d92475e7293
Quellennotizuspto-grants-2007_04