HuagongsheHuagongshe Chemie-Druckbericht · Nur für Forschungszwecke
HRID 1268686Erstellt: 24. Oktober 2026
Triethylamine → 2-[4-[4-Hydroxybut-1-ynyl]phenyl]-7-methylimidazo[1,2-a]pyridine
https://huagongshe.com/de/reaction/1268686
Beteiligte Stoffe
| Rolle | Name | HCID | Einwaage |
|---|
| Edukt | Triethylamine | HCID 8471 | — |
| Edukt | 3-Butyn-1-OL | HCID 13566 | — |
| Edukt | 2-(4-Bromophenyl)-7-methylimidazo[1,2-a]pyridine | HCID 717644 | — |
| Katalysator | Copper(1+) iodide; Copper(I) iodide; Cuprous iodide; Cuprous iodide (CuI) | HCID 24350 | — |
| Katalysator | HCID 178418397 | HCID 178418397 | — |
| Lösungsmittel | Acetonitrile | HCID 6342 | — |
| Produkt | 2-[4-[4-Hydroxybut-1-ynyl]phenyl]-7-methylimidazo[1,2-a]pyridine | HCID 22015594 | 71,7% |
Reaktionsschritte
The product of Step A (1.8 g) in dry acetonitrile (40 mL) was treated sequentially with tetrakis(triphenylphosphine)palladium(0) (0.1 g), triethylamine (1.27 g), and CuI (10 mg) then heated at 60° C. for 30 minutes. The mixture was cooled to ambient temperature, treated with 3-butyn-1-ol (0.361 g) and heated at reflux temperature for 18 hours. The mixture was cooled to ambient temperature and evaporated to dryness. The residue was crystallized, twice, from acetone to afford the title compound (1.02 g).
Herkunft & Nachweise
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patentnummer | US07199117B2 |
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| Quelldatensatz | uspto-grants-2007_04 |
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| ORD ID | ord-42f904bf8fa3461590766760e228b820 |
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| Quellennotiz | uspto-grants-2007_04 |
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