N-[3-(4-Piperidinyl)phenyl]butanamide → Tert-butyl 4-{3-[(cyclopropylcarbonyl)amino)phenyl}-1-piperidinecarboxylate

HRID 1269137

Reaktionsgleichung

Reaktionsgleichung von HRID 1269137
[NH:1]1[CH2:6][CH2:5][CH:4]([C:7]2[CH:8]=[C:9]([NH:13][C:14]([CH:16]3[CH2:18][CH2:17]3)=[O:15])[CH:10]=[CH:11][CH:12]=2)[CH2:3][CH2:2]1.N1CC[CH:22]([C:25]2[CH:26]=C(NC(=O)CCC)C=C[CH:30]=2)CC1.CN(C)C(NC1C=CC=C(C2CCNCC2)C=1)=O.N1CCC(C2C=C(N[C:68](=[O:77])[O:69]CC3C=CC=CC=3)C=CC=2)CC1.CC(C)C(NC1C=CC(C2CCNCC2)=CC=1)=O.N1CCC(C2C=CC(NC(=O)CCC)=CC=2)CC1>>[C:25]([O:77][C:68]([N:1]1[CH2:6][CH2:5][CH:4]([C:7]2[CH:12]=[CH:11][CH:10]=[C:9]([NH:13][C:14]([CH:16]3[CH2:17][CH2:18]3)=[O:15])[CH:8]=2)[CH2:3][CH2:2]1)=[O:69])([CH3:22])([CH3:30])[CH3:26]

Komponenten

7

Edukt 6

HCID 18446869N-[3-(4-Piperidinyl)phenyl]butanamideHCID 219572582-methyl-N-[4-(4-piperidinyl)phenyl]propanamideHCID 21957274N-[4-(4-piperidinyl)phenyl]butanamideHCID 22048669N-[3-(4-Piperidinyl)phenyl]cyclopropanecarboxamideHCID 69630813Benzyl 3-(4-piperidinyl)phenylcarbamateHCID 85998569N,N-Dimethyl-N'-[3-(4-piperidinyl)phenyl]urea

Produkt 1

HCID 22049153Tert-butyl 4-{3-[(cyclopropylcarbonyl)amino)phenyl}-1-piperidinecarboxylate

Versuchsvorschrift

ESMS m/e: 345.5 (M+H)+; N-[3-(4-PIPERIDINYL) PHENYL]CYCLOPROPANECARBOXAMIDE: ESMS m/e: 245.0 (M+H)+; N-[3-(4-PIPERIDINYL)PHENYL]BUTANAMIDE: ESMS m/e: 247.3 (M+H)+; N,N-DIMETHYL-N′-[3-(4-PIPERIDINYL) PHENYL]UREA: ESMS m/e: 248.2 (M+H)+; ISOPROPYL 3-(4-PIPERIDINYL)PHENYL CARBAMATE: ESMS m/e: 263.4 (M+H)+; BENZYL 3-(4-PIPERIDINYL)PHENY LCARBAMATE: ESMS m/e: 311.3 (M+H)+; 2-METHYL-N-[4-(4-PIPERIDINYL)PHENYL]PROPANAMIDE: ESMS m/e: 247.1 (M+H)+; N-[4-(4-PIPERIDINYL)PHENYL]BUTANAMIDE: ESMS m/e: 247.2 (M+H)+.

Quellen und Nachweise

ORD-Eintrag
ord-b3682c2624174f3eb005e9c11819bda8
Quelldatensatz
uspto-grants-2007_04
Patentnummer
US07199135B2

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