N-bromobutanimide → 1H-Indazol-5-ol,4-broMo-

HRID 1269919Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1269919
[Br:1]N1C(=O)CCC1=O.[NH:9]1[C:17]2[C:12](=[CH:13][C:14]([OH:18])=[CH:15][CH:16]=2)[CH:11]=[N:10]1>O1CCCC1>[Br:1][C:13]1[C:14]([OH:18])=[CH:15][CH:16]=[C:17]2[C:12]=1[CH:11]=[N:10][NH:9]2

Komponenten

4

Edukt 2

HCID 67184N-bromobutanimideHCID 1014381H-Indazol-5-ol

Produkt 1

HCID 229341081H-Indazol-5-ol,4-broMo-Ausbeute 91 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 8028TetrahydrofuranLösungsmittel

Versuchsvorschrift

N-bromosuccinimide (1.06 g, 5.96 mmol) was added to a solution of the 1H-indazol-5-ol (800 mg, 5.96 mmol) obtained in Reference Example 4 in tetrahydrofuran (20 ml) at room temperature. The resulting mixture was stirred for 14 hours while being maintained at room temperature. The mixture was concentrated under reduced pressure and the resulting residue was purified by a silica gel column chromatography (eluent: hexane/ethyl acetate) to obtain 4-bromo-1H-indazol-5-ol (1.15 g, 91%).

Aufarbeitung

  1. concentrationThe mixture was concentrated under reduced pressure
  2. customthe resulting residue was purified by a silica gel column chromatography (eluent: hexane/ethyl acetate)

Quellen und Nachweise

ORD-Eintrag
ord-71418cc7433644339b4d46e5fc3fbccc
Quelldatensatz
uspto-grants-2007_04
Patentnummer
US07199147B2

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