Trifluoroacetic acid → 4-(3-Bromo-4-methoxyphenoxy)-3,5-dimethylnitrobenzene

HRID 1270604

Reaktionsgleichung

Reaktionsgleichung von HRID 1270604
[CH3:1][C:2]1[CH:3]=[C:4]([N+:18]([O-:20])=[O:19])[CH:5]=[C:6]([CH3:17])[C:7]=1[O:8][C:9]1[CH:14]=[CH:13][C:12]([O:15][CH3:16])=[CH:11][CH:10]=1.[Br:21]N1C(=O)CCC1=O.FC(F)(F)C(O)=O>C(Cl)(Cl)Cl>[Br:21][C:13]1[CH:14]=[C:9]([CH:10]=[CH:11][C:12]=1[O:15][CH3:16])[O:8][C:7]1[C:6]([CH3:17])=[CH:5][C:4]([N+:18]([O-:20])=[O:19])=[CH:3][C:2]=1[CH3:1]

Komponenten

5

Edukt 3

HCID 6422Trifluoroacetic acid2×HCID 67184N-bromobutanimide2×HCID 100846724-(4-Methoxy-phenoxy)-3,5-dimethyl-nitrobenzene

Produkt 1

HCID 223397284-(3-Bromo-4-methoxyphenoxy)-3,5-dimethylnitrobenzeneAusbeute 97,2 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 6212ChloroformLösungsmittel

Versuchsvorschrift

To a solution of 3,5-dimethyl-4-(4′-methoxyphenoxy)nitrobenzene (4.0 g) (J. Med. Chem., 38: 703 (1995)) in chloroform (150 ml) were added N-bromosuccinimide (2.6 g) and trifluoroacetic acid (1.1 ml), and the resulting mixture was heated under reflux for 90 min. Additional portions of N-bromosuccinimide (2.6 g) and trifluoroacetic acid (1.1 ml) were added, followed by further heating for 18 h. The reaction was washed with sodium bicarbonate, dried (Na2SO4) and concentrated to afford the title compound of Step A as an orange solid (5.0 g). MS (APCI+) Calc: 351; Found: 352 (M+1).

Aufarbeitung

  1. temperaturethe resulting mixture was heated
  2. temperatureunder reflux for 90 min
  3. temperatureby further heating for 18 h
  4. washThe reaction was washed with sodium bicarbonate
  5. dry with materialdried (Na2SO4)
  6. concentrationconcentrated

Quellen und Nachweise

ORD-Eintrag
ord-02fef635b7174876828231d3888003cc
Quelldatensatz
uspto-grants-2007_04
Patentnummer
US07202275B2

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