Ethanol → 1-[3-(Benzyloxy)phenyl]-2-(formylamino)ethane

HRID 1271243

Reaktionsgleichung

Reaktionsgleichung von HRID 1271243
[CH2:1]([O:8][C:9]1[CH:10]=[C:11]([CH2:15][CH2:16][NH2:17])[CH:12]=[CH:13][CH:14]=1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[CH2:18]([OH:20])C>C(OCC)=O>[CH2:1]([O:8][C:9]1[CH:10]=[C:11]([CH2:15][CH2:16][NH:17][CH:18]=[O:20])[CH:12]=[CH:13][CH:14]=1)[C:2]1[CH:3]=[CH:4][CH:5]=[CH:6][CH:7]=1

Komponenten

4

Edukt 2

HCID 702EthanolHCID 2074152-(3-(Benzyloxy)phenyl)ethanamine

Produkt 1

HCID 229319731-[3-(Benzyloxy)phenyl]-2-(formylamino)ethane

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 8025Ethyl formateLösungsmittel

Versuchsvorschrift

To a solution of 8.60 g of 2-[3-(benzyloxy)phenyl]ethylamine in 50 ml of ethanol, 4.6 ml of ethyl formate was added and the mixture was heated at reflux for 18 hours. The solvent was evaporated under reduced pressure and the residue was purified by silica gel column chromatography to obtain 4.81 g of the desired compound as a pale orange oily substance.

Aufarbeitung

  1. temperaturethe mixture was heated
  2. temperatureat reflux for 18 hours
  3. customThe solvent was evaporated under reduced pressure
  4. customthe residue was purified by silica gel column chromatography

Quellen und Nachweise

ORD-Eintrag
ord-8939681e3cad4e74a0f12206f384ff5a
Quelldatensatz
uspto-grants-2007_04
Patentnummer
US07205302B2

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