Hydrochloric Acid → 5-(2-fluoro-3-pyridinyl)-2,4(1H,3H)-pyrimidinedione hydrochloride

HRID 12713

Reaktionsgleichung

Reaktionsgleichung von HRID 12713
[F:1][C:2]1[C:7]([C:8]2[C:9]([O:16]C)=[N:10][C:11]([O:14]C)=[N:12][CH:13]=2)=[CH:6][CH:5]=[CH:4][N:3]=1.O1CCOCC1.[ClH:24]>>[ClH:24].[F:1][C:2]1[C:7]([C:8]2[C:9](=[O:16])[NH:10][C:11](=[O:14])[NH:12][CH:13]=2)=[CH:6][CH:5]=[CH:4][N:3]=1

Komponenten

4

Edukt 3

HCID 313Hydrochloric AcidHCID 312751,4-DioxaneHCID 589941555-(2-Fluoro-3-pyridinyl)-2,4-bis(methyloxy)pyrimidine

Produkt 1

HCID 686945025-(2-fluoro-3-pyridinyl)-2,4(1H,3H)-pyrimidinedione hydrochloride

Versuchsvorschrift

A solution of 5-(2-fluoro-3-pyridinyl)-2,4-bis(methyloxy)pyrimidine (Prep87, 2.8 g, 11.90 mmol) in HCl 4M in 1,4dioxane (42 mL, 168 mmol) was heated at 90° C. for 1 h. A white precipitate crashed out of the solution. Volatiles were evaporated under reduced pressure to give title compound, pale yellow solid (2.75 g).

Aufarbeitung

  1. customVolatiles were evaporated under reduced pressure

Quellen und Nachweise

ORD-Eintrag
ord-7dfa12c1ad044b53834cd890affd01db
Quelldatensatz
uspto-grants-2010_06
Patentnummer
US07727988B2

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