Methylamine → N-(4-methyl-1,3-dioxan-2-ylmethyl)methylamine

Temperatur

50 °C

2-bromomethyl-4-methyl-1,3-dioxane (160 grams) and 40% aqueous methylamine (150 ml) were charged into a pressure vessel and agitated for a period of about 6 hours at a temperature of about 50° C. under autogeneous pressure. The reaction mixture was cooled to room temperature and sodium hydroxide (40 grams) was added. The reaction mixture was then extracted with methylene chloride. The extract was dried and the methylene chloride stripped off using a rotary evaporator to yield the desired product N-(4-methyl-1,3-dioxan-2-ylmethyl)methylamine.

1. temperatureThe reaction mixture was cooled to room temperature
2. extractionThe reaction mixture was then extracted with methylene chloride
3. customThe extract was dried
4. customa rotary evaporator

ORD-Eintrag

ord-fe87e18df2f843abb07459b083fed972

Quelldatensatz

uspto-grants-1981_03

DOI

10.6084/m9.figshare.5104873.v1

Patentnummer

US04255182