Trifluoroacetic acid → 2-(Thiophen-2-yl)ethene-1-sulfonamide

HRID 1272080Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1272080
CC([NH:9][S:10](/[CH:13]=[CH:14]/[C:15]1[S:16][CH:17]=[CH:18][CH:19]=1)(=[O:12])=[O:11])(C)CC(C)(C)C.FC(F)(F)C(O)=O>ClCCl>[S:16]1[CH:17]=[CH:18][CH:19]=[C:15]1/[CH:14]=[CH:13]/[S:10]([NH2:9])(=[O:11])=[O:12]

Komponenten

4

Edukt 2

HCID 6422Trifluoroacetic acidHCID 86609959(E)-2-thiophen-2-yl-ethenesulfonic acid (1,1,3,3-tetramethyl-butyl)-amide

Produkt 1

HCID 149124362-(Thiophen-2-yl)ethene-1-sulfonamideAusbeute 89 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 6344DichloromethaneLösungsmittel

Versuchsvorschrift

(E)-2-Thiophen-2-yl-ethenesulfonic acid (1,1,3,3-tetramethyl-butyl)-amide (5.17 g, 17.2 mmol) was stirred for 15 minutes in a 1:1 mixture of trifluoroacetic acid and dichloromethane (40 mL). The mixture was concentrated in vacuo to afford a solid that was washed with dichloromethane (10 mL) in heptane (100 mL). The resultant solid was collected by suction filtration and dried under vacuum at ambient temperature to afford (E)-2-thiophen-2-yl-ethenesulfonic acid amide (2.89 g, 89%).

Aufarbeitung

  1. concentrationThe mixture was concentrated in vacuo
  2. customto afford a solid
  3. washthat was washed with dichloromethane (10 mL) in heptane (100 mL)
  4. filtrationThe resultant solid was collected by suction filtration
  5. customdried under vacuum at ambient temperature

Quellen und Nachweise

ORD-Eintrag
ord-9bd2d0fefc85440e8a56200460a461ff
Quelldatensatz
uspto-grants-2007_04
Patentnummer
US07208506B2

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