Trifluoroacetic acid → (1E)-2-(4-Chlorophenyl)ethenesulfonamide

HRID 1272355Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1272355
CC([NH:9][S:10](/[CH:13]=[CH:14]/[C:15]1[CH:20]=[CH:19][C:18]([Cl:21])=[CH:17][CH:16]=1)(=[O:12])=[O:11])(C)CC(C)(C)C.FC(F)(F)C(O)=O>ClCCl>[Cl:21][C:18]1[CH:17]=[CH:16][C:15](/[CH:14]=[CH:13]/[S:10]([NH2:9])(=[O:11])=[O:12])=[CH:20][CH:19]=1

Komponenten

4

Edukt 2

HCID 6422Trifluoroacetic acidHCID 17748075(E)-2-(4-chloro-phenyl)-ethenesulfonic acid (1,1,3,3-tetramethyl-butyl)-amide

Produkt 1

HCID 6212331(1E)-2-(4-Chlorophenyl)ethenesulfonamideAusbeute 89,2 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 6344DichloromethaneLösungsmittel

Versuchsvorschrift

To (E)-2-(4-chloro-phenyl)-ethenesulfonic acid (1,1,3,3-tetramethyl-butyl)-amide (5.0 g, 15.2 mmol) in dichloromethane (10 ml) was added trifluoroacetic acid (10 ml) and the mixture was stirred for 15 min. The mixture was concentrated in vacuo to afford a solid. The solid was washed with dichloromethane (5 ml) and heptane (150 ml). The resultant solid was collected by suction filtration. The solid was dried under vacuum at room temperature to afford (E)-2-(4-chloro-phenyl)-ethenesulfonic acid amide (2.95 g, 89%).

Aufarbeitung

  1. concentrationThe mixture was concentrated in vacuo
  2. customto afford a solid
  3. washThe solid was washed with dichloromethane (5 ml) and heptane (150 ml)
  4. filtrationThe resultant solid was collected by suction filtration
  5. customThe solid was dried under vacuum at room temperature

Quellen und Nachweise

ORD-Eintrag
ord-f0e02833935c49e3bb4fd045b332985c
Quelldatensatz
uspto-grants-2007_04
Patentnummer
US07208526B2

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