Acetone → 1-(2-Hydroxy-3-n-hexadecyloxypropyl)-4-phenylpiperidine

HRID 127254Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 127254
[C:1]1([CH:7]2[CH2:12][CH2:11][NH:10][CH2:9][CH2:8]2)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.O1CC1C[CH:16]([O:32][CH:33]([CH2:49][CH:50]1OC1)CCCCCCCCCCCCCCC)[CH2:17][CH2:18][CH2:19][CH2:20][CH2:21][CH2:22][CH2:23][CH2:24][CH2:25][CH2:26][CH2:27][CH2:28][CH2:29][CH2:30][CH3:31].CC(C)=[O:56]>>[OH:56][CH:49]([CH2:33][O:32][CH2:16][CH2:17][CH2:18][CH2:19][CH2:20][CH2:21][CH2:22][CH2:23][CH2:24][CH2:25][CH2:26][CH2:27][CH2:28][CH2:29][CH2:30][CH3:31])[CH2:50][N:10]1[CH2:9][CH2:8][CH:7]([C:1]2[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=2)[CH2:12][CH2:11]1

Komponenten

4

Edukt 3

HCID 180AcetoneHCID 698734-PhenylpiperidineHCID 180000852,3-Epoxypropyl-n-hexadecylether

Produkt 1

HCID 130378071-(2-Hydroxy-3-n-hexadecyloxypropyl)-4-phenylpiperidineAusbeute 50 %

Reaktionsbedingungen

Temperatur
180 °C

Versuchsvorschrift

4-Phenylpiperidine (1.8 g, 0.011 mol) and 2,3-epoxypropyl-n-hexadecylether (2.98 g, 0.01 mol) were combined and heated to 180° C. for 30 minutes. The reaction mixture was cooled, acetone was added, and the mixture was stirred for 16 hours. The resulting solids were collected and recrystallized from hot acetone to give pure product (2.3 g, 50% yield): mp 64°-65° C.

Aufarbeitung

  1. temperatureThe reaction mixture was cooled
  2. customThe resulting solids were collected
  3. customrecrystallized from hot acetone

Quellen und Nachweise

ORD-Eintrag
ord-9679826e97e14bcd854a82e8314045c7
Quelldatensatz
uspto-grants-1981_03
Patentnummer
US04255426

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