2-chloro-N-[2-[(2-chloro-9-cyclopentyl-9H-purin-6-yl)-amino]-ethyl]-4-nitro-benzamide → HCID 178478741, Verbindung
Reaktionsgleichung
[Cl:1][C:2]1[CH:28]=[C:27]([N+:29]([O-:31])=[O:30])[CH:26]=[CH:25][C:3]=1[C:4]([NH:6][CH2:7][CH2:8][NH:9][C:10]1[N:18]=[C:17](Cl)[N:16]=[C:15]2[C:11]=1[N:12]=[CH:13][N:14]2[CH:20]1[CH2:24][CH2:23][CH2:22][CH2:21]1)=[O:5].[NH2:32][C@H:33]1[CH2:38][CH2:37][C@H:36]([NH2:39])[CH2:35][CH2:34]1>>[ClH:1].[ClH:1].[NH2:32][C@H:33]1[CH2:38][CH2:37][C@H:36]([NH:39][C:17]2[N:16]=[C:15]3[C:11]([N:12]=[CH:13][N:14]3[CH:20]3[CH2:21][CH2:22][CH2:23][CH2:24]3)=[C:10]([NH:9][CH2:8][CH2:7][NH:6][C:4](=[O:5])[C:3]3[CH:25]=[CH:26][C:27]([N+:29]([O-:31])=[O:30])=[CH:28][C:2]=3[Cl:1])[N:18]=2)[CH2:35][CH2:34]1Komponenten
3
Reaktionsbedingungen
- Temperatur
- 140 °C
Versuchsvorschrift
295 mg of the product obtained in Stage 1 above and 362 mg of trans-1,4-diaminocyclohexane are mixed together and the reaction medium is heated to approximately 140° C. for 6 hours. After evaporating the solvent, chromatography on silica is carried out (eluent methylene chloride/ methanol/ammonium hydroxide 85/15/1.5) then taken up in an ethanolic solution of hydrochloric acid, followed by leaving to crystallize, separating, drying under reduced pressure and 105 mg of expected product is recovered.