(Quinolin-5-yl)methanamine → HCID 86595694, Verbindung
Reaktionsgleichung
[CH:1]1([CH2:4][NH:5][C:6]([C:8]2[CH:13]=[CH:12][C:11]([C:14]3[C:19]([CH3:20])=[CH:18][CH:17]=[C:16]([C:21]([OH:23])=O)[CH:15]=3)=[CH:10][CH:9]=2)=[O:7])[CH2:3][CH2:2]1.[NH2:24][CH2:25][C:26]1[CH:35]=[CH:34][CH:33]=[C:32]2[C:27]=1[CH:28]=[CH:29][CH:30]=[N:31]2>>[CH:1]1([CH2:4][NH:5][C:6]([C:8]2[CH:13]=[CH:12][C:11]([C:14]3[C:19]([CH3:20])=[CH:18][CH:17]=[C:16]([C:21]([NH:24][CH2:25][C:26]4[CH:35]=[CH:34][CH:33]=[C:32]5[C:27]=4[CH:28]=[CH:29][CH:30]=[N:31]5)=[O:23])[CH:15]=3)=[CH:10][CH:9]=2)=[O:7])[CH2:3][CH2:2]1Komponenten
3
Versuchsvorschrift
N4′-Cyclopropylmethyl-6-methyl-N3-(quinolin-5-ylmethyl)-1,1′-biphenyl-3,4′-dicarboxamide was synthesised from {4′-[(cyclopropylmethylamino)carbonyl]-6-methyl-1,1′-biphenyl-3-yl}carboxylic acid and 5-aminomethylquinoline using method A. NMR: δH [2H6]-DMSO 9.11, (1H, t), 8.91, (1H, dd), 8.65–8.60, (2H, m), 7.95–7.91, (3H, m), 7.84, (1H, dd), 7.78, (1H, d), 7.72, (1H, t), 7.58–7.55, (2H, m), 7.46, (2H, d), 7.41, (1H, d), 4.95, (2H, d), 3.15, (2H, t), 2.27, (3H, s), 1.03, (1H, m), 0.42, (2H, m), 0.23, (2H, m). LCMS: retention time 3.15 min, MH+450.
Quellen und Nachweise
- ORD-Eintrag
- ord-4a9031b0d43c4e32a1294d389d2bb10b
- Quelldatensatz
- uspto-grants-2007_04