[NH2:1][C@H:2]([C:5]([OH:7])=[O:6])[CH2:3][SH:4].[CH3:8][C:9]([S:14][CH3:15])([CH3:13])[C:10](Cl)=[O:11].Cl>C(=O)([O-])[O-].[K+].[K+]>[CH3:8][C:9]([S:14][CH3:15])([CH3:13])[C:10]([NH:1][C@H:2]([C:5]([OH:7])=[O:6])[CH2:3][SH:4])=[O:11]L-Cysteine (7.1 g) is dissolved in 88 ml of 2 M potassium carbonate and 7.5 g of 2-methyl-2-(methylthio)propanoyl chloride [b.p. 78° C. (37 mmHg)] is added dropwise while stirring under a nitrogen atmosphere at 0° C. After the addition, the mixture is stirred overnight at room temperature. The mixture is acidified with hydrochloric acid and the obtained crystals are separated by filtration and dried to yield 10.4 g (89.8%) of the titled compound.
Wird geladen…
