HCID 58994249, Verbindung → HCID 58994157, Verbindung

HRID 12735Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 12735
C[O:2][CH:3](OC)[CH2:4][CH2:5][N:6]1[CH:11]=[C:10]([C:12]2[CH:13]=[N:14][CH:15]=[CH:16][C:17]=2[CH3:18])[C:9](=[O:19])[NH:8][C:7]1=[O:20]>C1COCC1>[CH3:18][C:17]1[CH:16]=[CH:15][N:14]=[CH:13][C:12]=1[C:10]1[C:9](=[O:19])[NH:8][C:7](=[O:20])[N:6]([CH2:5][CH2:4][CH:3]=[O:2])[CH:11]=1

Komponenten

3

Edukt 1

HCID 58994249HCID 58994249, Verbindung

Produkt 1

HCID 58994157HCID 58994157, Verbindung

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 8028TetrahydrofuranLösungsmittel

Reaktionsbedingungen

Temperatur
40 °C

Versuchsvorschrift

1-(3,3-Dimethoxy-propyl)-5-(4-methyl-pyridin-3-yl)-1H-pyrimidine-2,4-dione (Pre112, 100 mg, 0.32 mmol) was dissolved in THF (5 ml) and 1N HClaq (327 μl) was added. The solution was then stirred at 40° C. for 1.5 hours. TEA (45 μl) was added and the solvent was carefully removed in vacuum at room temperature. Residue was freeze dried to give the title compound that was used in the next step without further purification (quantitative yield).

Aufarbeitung

  1. addition1N HClaq (327 μl) was added
  2. customthe solvent was carefully removed in vacuum at room temperature
  3. customdried

Quellen und Nachweise

ORD-Eintrag
ord-ec7bd10461df43f8b74b205be880fb9b
Quelldatensatz
uspto-grants-2010_06
Patentnummer
US07727988B2

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