2-Aminomethyl-1-ethylpyrrolidine → N-(1-ethyl-2-pyrrolidylmethyl)-7-methylsulfamoyl-1,4-benzodioxane-5-carboxamide

HRID 127412

Reaktionsgleichung

Reaktionsgleichung von HRID 127412
[CH2:1]([N:3]1[CH2:7][CH2:6][CH2:5][CH:4]1[CH2:8][NH2:9])[CH3:2].[CH3:10][NH:11][S:12]([C:15]1[CH:16]=[C:17]([C:25](Cl)=[O:26])[C:18]2[O:23][CH2:22][CH2:21][O:20][C:19]=2[CH:24]=1)(=[O:14])=[O:13]>>[CH2:1]([N:3]1[CH2:7][CH2:6][CH2:5][CH:4]1[CH2:8][NH:9][C:25]([C:17]1[C:18]2[O:23][CH2:22][CH2:21][O:20][C:19]=2[CH:24]=[C:15]([S:12](=[O:14])(=[O:13])[NH:11][CH3:10])[CH:16]=1)=[O:26])[CH3:2]

Komponenten

3

Edukt 2

HCID 1172952-Aminomethyl-1-ethylpyrrolidineHCID 205447207-Methylsulfamoyl-1,4-benzodioxane-5-carbonyl chloride

Produkt 1

HCID 24834932N-(1-ethyl-2-pyrrolidylmethyl)-7-methylsulfamoyl-1,4-benzodioxane-5-carboxamideAusbeute 62 %

Versuchsvorschrift

In a similar manner to that of the above example, 82 g of levorotatory 1-ethyl-2-aminomethyl-pyrrolidine was reacted with 195 g of 7-methylsulfamoyl-1,4-benzodioxane-5-carbonyl chloride to give 151 g of levorotatory-N-(1-ethyl-2-pyrrolidylmethyl)-7-methylsulfamoyl-1,4-benzodioxane-5-carboxamide (M.P.: 136°-137° C.; yield: 62%).

Quellen und Nachweise

ORD-Eintrag
ord-5af84340bff742c38aab618287465b2d
Quelldatensatz
uspto-grants-1981_03
Patentnummer
US04255580

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