Thionyl Chloride → 3-(2-Biphenylyl)-2-ethylpropionyl chloride

HRID 1274381

Reaktionsgleichung

Reaktionsgleichung von HRID 1274381
[C:1]1([C:14]2[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=2)[CH:6]=[CH:5][CH:4]=[CH:3][C:2]=1[CH2:7][CH:8]([CH2:12][CH3:13])[C:9](O)=[O:10].S(Cl)([Cl:22])=O>>[C:1]1([C:14]2[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=2)[CH:6]=[CH:5][CH:4]=[CH:3][C:2]=1[CH2:7][CH:8]([CH2:12][CH3:13])[C:9]([Cl:22])=[O:10]

Komponenten

3

Edukt 2

HCID 24386Thionyl ChlorideHCID 215719833-(2-Biphenylyl)-2-ethylpropionic acid

Produkt 1

HCID 223402173-(2-Biphenylyl)-2-ethylpropionyl chlorideAusbeute 106,3 %

Versuchsvorschrift

To a 300-ml three-necked round flask (equipped with a stirrer tip, a Zimroth condenser, a thermometer and a NaOH trap) were fed 39.9 g (157.2 mmol) of 3-(2-biphenylyl)-2-ethylpropionic acid and 77.7 ml (1,065 mmol) of thionyl chloride, and the contents in the flask were refluxed for 2.5 hours in a nitrogen atmosphere. After the reaction was completed, the unreacted thionyl chloride was distilled off under reduced pressure to obtain 45.6 g of a coarse product of an yellow-orange liquid. This acid chloride was used for the next reaction without any further purification.

Aufarbeitung

  1. customTo a 300-ml three-necked round flask (equipped with a stirrer tip
  2. temperaturethe contents in the flask were refluxed for 2.5 hours in a nitrogen atmosphere
  3. distillationthe unreacted thionyl chloride was distilled off under reduced pressure

Quellen und Nachweise

ORD-Eintrag
ord-22a828ed0c9149a6841496306782a51a
Quelldatensatz
uspto-grants-2000_12
Patentnummer
US06156844

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