HCID 58994226, Verbindung → HCID 58994178, Verbindung
Reaktionsgleichung
C[O:2][CH:3](OC)[CH2:4][CH2:5][N:6]1[CH:11]=[C:10]([C:12]2[CH:17]=[N:16][CH:15]=[CH:14][N:13]=2)[C:9](=[O:18])[NH:8][C:7]1=[O:19]>C1COCC1>[O:19]=[C:7]1[NH:8][C:9](=[O:18])[C:10]([C:12]2[CH:17]=[N:16][CH:15]=[CH:14][N:13]=2)=[CH:11][N:6]1[CH2:5][CH2:4][CH:3]=[O:2]Komponenten
3
Reagenzien, Katalysatoren, Lösungsmittel 1
Reaktionsbedingungen
- Temperatur
- 40 °C
Versuchsvorschrift
1-(3,3-Dimethoxy-propyl)-5-pyrazin-2-yl-1H-pyrimidine-2,4-dione (Prep126, 111 mg, 0.38 mmol) was dissolved in THF (4 ml) and then 1N HClaq (0.38 ml) was added. The solution was stirred at 40° C. for 4 hours. TEA (55 μl, 0.39 mmol) was added and the solvent was removed in vacuum at room temperature. Residue was freeze dried to give a white powder that was used in the next step without further purification (quantitative yield).