2-Thiopheneacetyl chloride → Methyl 4-chloro-5-nitro-2-(2-(thiophen-2-yl)acetamido)benzoate

Beteiligte Stoffe

Reaktionsschritte

To a suspension of 2-amino-4-chloro-5-nitrobenzoic acid methyl ester (221 mg in 2.5 mL of dry 1,2-dichloroethane) was added a solution of thiophen-2-yl-acetyl chloride (169 mg in 3.0 mL dry 1,2-dichloroethane) and the mixture heated at reflux on an oil bath. After 18 hours, the reaction was cooled and the solvent removed in vacuo. Recrystallization of the crude product from methanol gave the title compound (230 mg).

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