Toluene → 7-Methyl-6-(2-imidazolinylamino)indole
Reaktionsgleichung
[N:1]([C:4]1[C:12]([CH3:13])=[C:11]2[C:7]([CH:8]=[CH:9][NH:10]2)=[CH:6][CH:5]=1)=C=S.[CH2:14]([NH2:17])[CH2:15][NH2:16].[C:18]1(C)C=CC=CC=1>>[CH3:13][C:12]1[C:4]([NH:1][N:16]2[CH2:15][CH2:14][N:17]=[CH:18]2)=[CH:5][CH:6]=[C:7]2[C:11]=1[NH:10][CH:9]=[CH:8]2Komponenten
4
Versuchsvorschrift
A solution of 6-isothiocyanato-7-methylindole (0.85 g, 4.52 mmol) in 25 mL of toluene is added to a solution of ethylenediamine (1.06 mL, 15.8 mmol) in 50 mL of toluene. The milky white mixture is stirred for 30 minutes as the desired product precipitates. The reaction is filtered to yield 1.1 g of 6-[-N'-(2-aminoethyl)thioureido]-7-methylindole as a flaky white solid (99% yield).
Quellen und Nachweise
- ORD-Eintrag
- ord-3a97ea4877b54c01b86c028b4180851e