Hydrochloric Acid → 5-(trifluoromethyl)-1-(3-{(1S,5R)-1-[4-(trifluoromethyl)phenyl]-3-azabicyclo[3.1.0]hex-3-yl}propyl)-2,4(1H,3H)-pyrimidinedione hydrochloride

HRID 12757Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 12757
[F:1][C:2]([F:31])([F:30])[C:3]1[C:4](=[O:29])[NH:5][C:6](=[O:28])[N:7]([CH2:9][CH2:10][CH2:11][N:12]2[CH2:17][C@H:16]3[C@:14]([C:18]4[CH:23]=[CH:22][C:21]([C:24]([F:27])([F:26])[F:25])=[CH:20][CH:19]=4)([CH2:15]3)[CH2:13]2)[CH:8]=1.[ClH:32]>O1CCOCC1>[ClH:32].[F:31][C:2]([F:1])([F:30])[C:3]1[C:4](=[O:29])[NH:5][C:6](=[O:28])[N:7]([CH2:9][CH2:10][CH2:11][N:12]2[CH2:17][C@H:16]3[C@:14]([C:18]4[CH:19]=[CH:20][C:21]([C:24]([F:27])([F:26])[F:25])=[CH:22][CH:23]=4)([CH2:15]3)[CH2:13]2)[CH:8]=1

Komponenten

4

Edukt 2

HCID 313Hydrochloric AcidHCID 247590115-(trifluoromethyl)-1-(3-{(1S,5R)-1-[4-(trifluoromethyl)phenyl]-3-azabicyclo[3.1.0]hex-3-yl}propyl)-2,4(1H,3H)-pyrimidinedione

Produkt 1

HCID 866159515-(trifluoromethyl)-1-(3-{(1S,5R)-1-[4-(trifluoromethyl)phenyl]-3-azabicyclo[3.1.0]hex-3-yl}propyl)-2,4(1H,3H)-pyrimidinedione hydrochloride

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 312751,4-DioxaneLösungsmittel

Versuchsvorschrift

5-(trifluoromethyl)-1-(3-{(1S,5R)-1-[4-(trifluoromethyl)phenyl]-3-azabicyclo[3.1.0]hex-3-yl}propyl)-2,4(1H,3H)-pyrimidinedione was treated with a solution of 4N HCl in dioxane (200 μl) to give the title compound as a white solid. The salt was further purified by crystallization with IPA/DIPE to give after filtration 26 mg of title compound.

Quellen und Nachweise

ORD-Eintrag
ord-34a42722b8cd495d9d76caae747cba52
Quelldatensatz
uspto-grants-2010_06
Patentnummer
US07727988B2

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