Gadolinium → Gadobutrol (JAN/USAN/INN)

HRID 1275799

Reaktionsgleichung

Reaktionsgleichung von HRID 1275799
[Na+].[N:2]1([CH2:22][C:23]([O-:25])=[O:24])[CH2:13][CH2:12][NH:11][CH2:10][CH2:9][N:8]([CH2:14][C:15]([O-:17])=[O:16])[CH2:7][CH2:6][N:5]([CH2:18][C:19]([O-:21])=[O:20])[CH2:4][CH2:3]1.[Na+].[Na+].CC1(C)[O:36][CH2:35][CH:34]2[CH:32]([O:33]2)[CH2:31][O:30]1.[Gd:38]>>[CH2:4]1[N:5]([CH2:18][C:19]([O-:21])=[O:20])[CH2:6][CH2:7][N:8]([CH2:14][C:15]([O-:17])=[O:16])[CH2:9][CH2:10][N:11]([CH:34]([CH:32]([OH:33])[CH2:31][OH:30])[CH2:35][OH:36])[CH2:12][CH2:13][N:2]([CH2:22][C:23]([O-:25])=[O:24])[CH2:3]1.[Gd+3:38]

Komponenten

4

Edukt 3

HCID 23982GadoliniumHCID 108625271,4,7,10-tetraazacyclododecane-1,4,7-triacetic acid trisodium saltHCID 110947474,4-Dimethyl-3,5,8-trioxabicyclo[5.1.0]octane

Produkt 1

HCID 15814656Gadobutrol (JAN/USAN/INN)

Versuchsvorschrift

The solution of 1,4,7,10-tetraazacyclododecane-1,4,7-triacetic acid sodium salt is directly reacted, as described in EP 448191, with 4,4-dimethyl-3,5,8-trioxabicyclo[5.1.0]octane to give the alkylated product, which can, easily be complexed with gadolinium to give the final Gadobutrol.

Aufarbeitung

  1. customto give the alkylated product, which can,

Quellen und Nachweise

ORD-Eintrag
ord-b5ea5c9070954433ba820550abe7823e
Quelldatensatz
uspto-grants-2000_12
Patentnummer
US06162912

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