5-(5h-Dibenzo[a,d]cyclohepten-5-yl)-2,4(1h,3h)-pyrimidinedione → 4-[[5-{5H-Dibenzo[a,d]cyclohepten-5-yl}-3,4-dihydro-2,4-dioxo-1(2H)-pyrimidinyl]methyl]-2-thiophenecarboxylic acid, methyl ester

HRID 1275886Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1275886
Br[CH2:2][C:3]1[CH:4]=[C:5]([C:8]([O:10][CH3:11])=[O:9])[S:6][CH:7]=1.[CH:12]1[C:22]2[CH:21]=[CH:20][C:19]3[CH:23]=[CH:24][CH:25]=[CH:26][C:18]=3[CH:17]([C:27]3[C:28](=[O:34])[NH:29][C:30](=[O:33])[NH:31][CH:32]=3)[C:16]=2[CH:15]=[CH:14][CH:13]=1>>[CH:12]1[C:22]2[CH:21]=[CH:20][C:19]3[CH:23]=[CH:24][CH:25]=[CH:26][C:18]=3[CH:17]([C:27]3[C:28](=[O:34])[NH:29][C:30](=[O:33])[N:31]([CH2:2][C:3]4[CH:4]=[C:5]([C:8]([O:10][CH3:11])=[O:9])[S:6][CH:7]=4)[CH:32]=3)[C:16]=2[CH:15]=[CH:14][CH:13]=1

Komponenten

3

Edukt 2

HCID 110986755-(5h-Dibenzo[a,d]cyclohepten-5-yl)-2,4(1h,3h)-pyrimidinedioneHCID 15469145Methyl 4-(bromomethyl)thiophene-2-carboxylate

Produkt 1

HCID 867561254-[[5-{5H-Dibenzo[a,d]cyclohepten-5-yl}-3,4-dihydro-2,4-dioxo-1(2H)-pyrimidinyl]methyl]-2-thiophenecarboxylic acid, methyl ester

Versuchsvorschrift

The subtitle compound was prepared from the product of step (i) (0.29 g) and the product of example 1 step (iii) (0.373 g) according to the method of example 1 step (iv). Purification was by chromatography eluting with 10% ethyl acetate in toluene. Yield 0.34 g.

Aufarbeitung

  1. customPurification
  2. washeluting with 10% ethyl acetate in toluene

Quellen und Nachweise

ORD-Eintrag
ord-c66afc755fc2489c8c7a95b2846c9612
Quelldatensatz
uspto-grants-2000_12
Patentnummer
US06162808

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