5-Bromomethyl-2-furancarboxylic acid ethyl ester → 5-[[5-{2,8-Dichloro-5H-dibenzo[a,d]cyclohepten-5-yl}-3,4-dihydro-2,4-dioxo-1(2H)-pyrimidinyl]methyl]-2-furancarboxylic acid, ethyl ester

HRID 1275919

Reaktionsgleichung

Reaktionsgleichung von HRID 1275919
[Cl:1][C:2]1[CH:25]=[CH:24][C:5]2[CH:6]([C:16]3[C:17](=[O:23])[NH:18][C:19](=[O:22])[NH:20][CH:21]=3)[C:7]3[CH:14]=[CH:13][C:12]([Cl:15])=[CH:11][C:8]=3[CH:9]=[CH:10][C:4]=2[CH:3]=1.[CH2:26]([O:28][C:29]([C:31]1[O:32][C:33]([CH2:36]Br)=[CH:34][CH:35]=1)=[O:30])[CH3:27]>>[Cl:15][C:12]1[CH:13]=[CH:14][C:7]2[CH:6]([C:16]3[C:17](=[O:23])[NH:18][C:19](=[O:22])[N:20]([CH2:36][C:33]4[O:32][C:31]([C:29]([O:28][CH2:26][CH3:27])=[O:30])=[CH:35][CH:34]=4)[CH:21]=3)[C:5]3[CH:24]=[CH:25][C:2]([Cl:1])=[CH:3][C:4]=3[CH:10]=[CH:9][C:8]=2[CH:11]=1

Komponenten

3

Edukt 2

HCID 137895295-Bromomethyl-2-furancarboxylic acid ethyl esterHCID 221172515-[2,8-Dichloro-5H-dibenzo[a,d]cyclohepten-5-yl]-2,4(1H,3H)-pyrimidinedione

Produkt 1

HCID 867561305-[[5-{2,8-Dichloro-5H-dibenzo[a,d]cyclohepten-5-yl}-3,4-dihydro-2,4-dioxo-1(2H)-pyrimidinyl]methyl]-2-furancarboxylic acid, ethyl ester

Versuchsvorschrift

The subtitle compound was prepared from the product of step (vi) (0.54 g) and 5-bromomethyl-2-furancarboxylic acid ethyl ester (J. Chem. Soc. Perkin Trans. 1, 1981, 1125, Bull. Chem. Soc. Jpn. 1987, 60, 1807)(0.34 g) according to the method of example 1 step (iv). Purification was by chromatography eluting with 30% ethyl acetate in isohexane. Yield 0.55 g.

Aufarbeitung

  1. customPurification
  2. washeluting with 30% ethyl acetate in isohexane

Quellen und Nachweise

ORD-Eintrag
ord-3fd3a66ae35b499eac98efc94d7e60f7
Quelldatensatz
uspto-grants-2000_12
Patentnummer
US06162808

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