Sodium Hydroxide → Prinomide

HRID 127598

Reaktionsgleichung

Reaktionsgleichung von HRID 127598
[CH3:1][N:2]1[CH:6]=[CH:5][CH:4]=[C:3]1[C:7]1[O:11][N:10]=[CH:9][C:8]=1[C:12](=[O:20])[NH:13][C:14]1[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=1.[OH-].[Na+]>C(O)C>[CH3:1][N:2]1[CH:6]=[CH:5][CH:4]=[C:3]1[C:7](=[O:11])[CH:8]([C:12](=[O:20])[NH:13][C:14]1[CH:15]=[CH:16][CH:17]=[CH:18][CH:19]=1)[C:9]#[N:10]

Komponenten

4

Edukt 2

HCID 14798Sodium HydroxideHCID 202854115-(1-Methyl-2-pyrrolyl)-4-phenylcarbamoylisoxazole

Produkt 1

HCID 60352Prinomide

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 702EthanolLösungsmittel

Versuchsvorschrift

The solution of 0.3 g of 5-(1-methyl-2-pyrrolyl)-4-phenylcarbamoylisoxazole, 10 ml of 5% aqueous sodium hydroxide and the minimum amount of ethanol, is warmed on the steam cone for 5 minutes. It is filtered, acidified with 5 N hydrochloric acid and the crystals formed collected. They are washed with water and triturated with methanol to give the 1-methyl-β-oxo-α-phenylcarbamoyl-2-pyrrolpropionitrile melting at 170°-172°; it is identical with that prepared as described previously, i.e. Examples 1, 6, 9 or 10.

Aufarbeitung

  1. filtrationIt is filtered
  2. customthe crystals formed
  3. customcollected
  4. washThey are washed with water
  5. customtriturated with methanol

Quellen und Nachweise

ORD-Eintrag
ord-1a382aad4abc4c96bfb0adcedbcfb569
Quelldatensatz
uspto-grants-1981_03
Patentnummer
US04256759

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