Dichloromethane → H-Phe-Met-OMe.HCl

HRID 127604Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 127604
[NH:1](C(OC(C)(C)C)=O)[C@H:2]([C:10]([NH:12][C@H:13]([C:18]([O:20][CH3:21])=[O:19])[CH2:14][CH2:15][S:16][CH3:17])=[O:11])[CH2:3][C:4]1[CH:9]=[CH:8][CH:7]=[CH:6][CH:5]=1.C(Cl)[Cl:30]>Cl>[NH2:1][C@H:2]([C:10]([NH:12][C@H:13]([C:18]([O:20][CH3:21])=[O:19])[CH2:14][CH2:15][S:16][CH3:17])=[O:11])[CH2:3][C:4]1[CH:9]=[CH:8][CH:7]=[CH:6][CH:5]=1.[ClH:30]

Komponenten

4

Edukt 2

HCID 6344DichloromethaneHCID 8022451tert-Butoxycarbonyl-phenylalanyl-methionine methyl ester

Produkt 1

HCID 67685067H-Phe-Met-OMe.HCl

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 313Hydrochloric AcidLösungsmittel

Versuchsvorschrift

11.83 g of Boc-Phe-Met-OMe (see Biochemistry, 8, 4183 (1969), incorporated herein) is dissolved in 100 ml methylene chloride after which HCl is passed into the solution for about 40 minutes. After evaporation of the solution to dryness, 75 ml ethyl acetate is added, resulting in a precipitate. The solid substance is separated by filtration, washed with petroleum ether, and dried. Melting point 123°-124° C. Rf in To:EtOH (8:2)=0.43 on SiO2.

Aufarbeitung

  1. customAfter evaporation of the solution to dryness, 75 ml ethyl acetate
  2. additionis added
  3. customresulting in a precipitate
  4. customThe solid substance is separated by filtration
  5. washwashed with petroleum ether
  6. customdried

Quellen und Nachweise

ORD-Eintrag
ord-6c4d992ebbd846aa81b24e6a96ca344f
Quelldatensatz
uspto-grants-1981_03
Patentnummer
US04256736

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