Pyridine → L-Tryptophanamide

HRID 1276591Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1276591
Cl.CO[C:4](=[O:17])[C@H:5]([CH2:7][C:8]1[C:16]2[C:11](=[CH:12][CH:13]=[CH:14][CH:15]=2)[NH:10][CH:9]=1)[NH2:6].[N:18]1C=CC=CC=1>ClCCl>[NH2:6][C@H:5]([C:4]([NH2:18])=[O:17])[CH2:7][C:8]1[C:16]2[C:11](=[CH:12][CH:13]=[CH:14][CH:15]=2)[NH:10][CH:9]=1

Komponenten

4

Edukt 2

HCID 1049PyridineHCID 2734891Methyl tryptophanate hydrochloride

Produkt 1

HCID 439356L-Tryptophanamide

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 6344DichloromethaneLösungsmittel

Versuchsvorschrift

A solution of the active ester VIII (0.035 g, 0.06 mmol), L-tryptophan methyl ester hydrochloride (0.049 g, 0.19 mmol) and pyridine (0.015 g, 0.19 mmol) in dichloromethane (20 ml) was stirred overnight. The solvent was removed under reduced pressure and the residue purified by column chromatography (ethyl acetate elution) to yield the trytophan amide as a dark red crystalline solid.

Aufarbeitung

  1. customThe solvent was removed under reduced pressure
  2. customthe residue purified by column chromatography (ethyl acetate elution)

Quellen und Nachweise

ORD-Eintrag
ord-1b4fd1c1137a43baa4c47018ac7cf7d7
Quelldatensatz
uspto-grants-2000_12
Patentnummer
US06166202

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