Benzyl Bromide → 1-(Phenylmethyl)-1H-1,2,4-triazole

HRID 127660

Reaktionsgleichung

Reaktionsgleichung von HRID 127660
[CH2:1](Br)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[NH:9]1[CH:13]=[N:12][CH:11]=[N:10]1.C(=O)([O-])[O-].[K+].[K+]>C(#N)C>[CH2:1]([N:9]1[CH:13]=[N:12][CH:11]=[N:10]1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1

Komponenten

5

Edukt 3

HCID 7498Benzyl BromideHCID 92571H-1,2,4-TriazoleHCID 11430Potassium Carbonate

Produkt 1

HCID 224581-(Phenylmethyl)-1H-1,2,4-triazole

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 6342AcetonitrileLösungsmittel

Versuchsvorschrift

A mixture of 34.2 parts by weight of benzyl bromide, 13.8 parts by weight of 1,2,4-triazole and 41.4 parts by weight of potassium carbonate in 150 parts by weight of acetonitrile is refluxed for 10 hours while stirring. The mixture is filtered and the filtrate is evaporated to dryness and recrystallized from a mixture of toluene and cyclohexane. There is obtained 21 parts by weight of 1-benzyl-1,2,4-triazole; m.p.: 58° C.

Aufarbeitung

  1. temperatureis refluxed for 10 hours
  2. filtrationThe mixture is filtered
  3. customthe filtrate is evaporated to dryness
  4. customrecrystallized from a mixture of toluene and cyclohexane

Quellen und Nachweise

ORD-Eintrag
ord-26e929fcdfca4b17826444a9104df6a9
Quelldatensatz
uspto-grants-1981_03
Patentnummer
US04256754

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