1-[2-(4-Nitrophenyl)ethyl]piperidine → 4-(2-(Piperidin-1-yl)ethyl)aniline

HRID 1277024

Reaktionsgleichung

Reaktionsgleichung von HRID 1277024
[N+:1]([C:4]1[CH:9]=[CH:8][C:7]([CH2:10][CH2:11][N:12]2[CH2:17][CH2:16][CH2:15][CH2:14][CH2:13]2)=[CH:6][CH:5]=1)([O-])=O>C(O)C>[NH2:1][C:4]1[CH:9]=[CH:8][C:7]([CH2:10][CH2:11][N:12]2[CH2:17][CH2:16][CH2:15][CH2:14][CH2:13]2)=[CH:6][CH:5]=1

Komponenten

3

Edukt 1

HCID 2205731-[2-(4-Nitrophenyl)ethyl]piperidine

Produkt 1

HCID 107034004-(2-(Piperidin-1-yl)ethyl)anilineAusbeute 100,3 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 702EthanolLösungsmittel

Versuchsvorschrift

In ethanol (100 ml) was dissolved 1-[2-(4-nitrophenyl)ethyl]piperidine (24.8 g), and to the mixture was added dried 10% palladium on carbon(1.24 g). Under hydrogen atmosphere, the mixture was stirred at room temperature under atmospheric pressure for 86 hours. The palladium was filtered off, and the filtrate was concentrated to give 1-[2-(4-aminophenyl)ethyl]-piperidine (21.7 g) as pale brown oil.

Aufarbeitung

  1. additionto the mixture was added
  2. dry with materialdried 10% palladium on carbon(1.24 g)
  3. filtrationThe palladium was filtered off
  4. concentrationthe filtrate was concentrated

Quellen und Nachweise

ORD-Eintrag
ord-283da6d0723b47458453671459b96a32
Quelldatensatz
uspto-grants-2000_12
Patentnummer
US06166006

Verknüpfte Notizen

Wird geladen…