tert-Butyldimethyl((4-nitrobenzyl)oxy)silane → 4-Aminobenzyloxy-tert-butyldimethylsilane

HRID 1277033Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1277033
[C:1]([Si:5]([CH3:18])([CH3:17])[O:6][CH2:7][C:8]1[CH:13]=[CH:12][C:11]([N+:14]([O-])=O)=[CH:10][CH:9]=1)([CH3:4])([CH3:3])[CH3:2]>C(O)C>[NH2:14][C:11]1[CH:12]=[CH:13][C:8]([CH2:7][O:6][Si:5]([C:1]([CH3:2])([CH3:3])[CH3:4])([CH3:17])[CH3:18])=[CH:9][CH:10]=1

Komponenten

3

Edukt 1

HCID 11065418tert-Butyldimethyl((4-nitrobenzyl)oxy)silane

Produkt 1

HCID 110754704-Aminobenzyloxy-tert-butyldimethylsilaneAusbeute 94,2 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 702EthanolLösungsmittel

Versuchsvorschrift

In ethanol (80 ml) was dissolved tert-butyldimethyl-4-nitrobenzyloxysilane (16.5 g), and to the mixture was added dried 5% palladium on carbon (0.83 g). Under hydrogen atmosphere, the mixture was stirred at room temperature under atmospheric pressure for 7.5hours. The palladium was filtered off, and the filtrate was concentrated. The residue was separated and purified with column chromatography (ethyl acetate/hexane=1/4) to give 4-aminobenzyloxy-tert-butyldimethylsilane (13.8 g) as colorless oil.

Aufarbeitung

  1. additionto the mixture was added
  2. dry with materialdried 5% palladium on carbon (0.83 g)
  3. filtrationThe palladium was filtered off
  4. concentrationthe filtrate was concentrated
  5. customThe residue was separated
  6. custompurified with column chromatography (ethyl acetate/hexane=1/4)

Quellen und Nachweise

ORD-Eintrag
ord-d2b93e05d82747b2a58f3fc821d6adb4
Quelldatensatz
uspto-grants-2000_12
Patentnummer
US06166006

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