Potassium Hydroxide → 3-Isoxazolamine, 5-(1,1-dimethylethyl)-

Beteiligte Stoffe

Reaktionsschritte

To a suspension of pivaloylacetonitrile (1.252 g) and 86% potassium hydroxide (0.717 g) in water (20 ml) is added hydroxylamine sulfate (0.903 g) at 25° C. and the mixture is stirred for 3 minutes. pH 8.30. The reaction mixture is treated as in Example 2 to give 3-amino-5-t-butylisoxazole (1.204 g). Yield, 85.9%. Purity, 95.8%.

Herkunft & Nachweise