Iodine → 2-Hydroxymethyl-3-methyl-5-iodothiophene

HRID 127763

Reaktionsgleichung

Reaktionsgleichung von HRID 127763
[I:1]I.[OH:3][CH2:4][C:5]1[S:6][CH:7]=[CH:8][C:9]=1[CH3:10]>C1C=CC=CC=1>[OH:3][CH2:4][C:5]1[S:6][C:7]([I:1])=[CH:8][C:9]=1[CH3:10]

Komponenten

4

Edukt 2

HCID 807IodineHCID 12875263(3-Methylthiophen-2-yl)methanol

Produkt 1

HCID 191047842-Hydroxymethyl-3-methyl-5-iodothiophene

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 241BenzeneLösungsmittel

Versuchsvorschrift

6.58 G. (33 mmol) of mercuric oxide and 7.62 g. (30 mmol) of iodine were added alternately in small amounts to a vigorously stirred solution of 3.84 g. (30 mmol) of 2-hydroxymethyl-3-methylthiophene in 30 ml. of benzene. The reaction was kept at room temperature by cooling with an ice bath. The orange mercuric iodide which precipitated was filtered and washed well with benzene. The combined organic solutions were washed with sodium thiosulfate and saturated sodium chloride solution, dried and evaporated to yield crude 2-hydroxymethyl-3-methyl-5-iodothiophene as a colorless oil.

Aufarbeitung

  1. customwas kept at room temperature
  2. temperatureby cooling with an ice bath
  3. customThe orange mercuric iodide which precipitated
  4. filtrationwas filtered
  5. washwashed well with benzene
  6. washThe combined organic solutions were washed with sodium thiosulfate and saturated sodium chloride solution
  7. customdried
  8. customevaporated

Quellen und Nachweise

ORD-Eintrag
ord-8f91c11da0aa4924b866efa4a5fe7acc
Quelldatensatz
uspto-grants-1981_03
Patentnummer
US04256878

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