3-(Methylamino)-1-benzoxepin-5(2H)-one → HCID 13446113, Verbindung

HRID 1277930Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1277930
[CH3:1][NH:2][C:3]1[CH2:4][O:5][C:6]2[CH:14]=[CH:13][CH:12]=[CH:11][C:7]=2[C:8](=[O:10])[CH:9]=1.[H][H]>[Ni].C(O)C>[CH3:1][NH:2][CH:3]1[CH2:9][CH:8]([OH:10])[C:7]2[CH:11]=[CH:12][CH:13]=[CH:14][C:6]=2[O:5][CH2:4]1

Komponenten

5

Edukt 2

HCID 134460473-(Methylamino)-1-benzoxepin-5(2H)-oneHCID 178418361HCID 178418361, Verbindung

Produkt 1

HCID 13446113HCID 13446113, Verbindung

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 935NickelKatalysatorHCID 702EthanolLösungsmittel

Versuchsvorschrift

18.8 g (0.1 mole) 3-methylamino-1-benzoxepin-5(2H)-one is stirred with 40 g Raney Nickel in 400 ml ethanol for five hours at an hydrogen pressure of 55 bar. Subsequently, the catalyst is filtered out, the solvent is distilled off and one obtains 7.7 g (40% of the theoretical yield) racemic-2,3,4,5-tetrahydro-3-methylamino-1-benzoxepin-5-ol as an oil. The compound can be further separated as described earlier and further identified.

Aufarbeitung

  1. filtrationSubsequently, the catalyst is filtered out
  2. distillationthe solvent is distilled off
  3. customone obtains 7.7 g (40% of the

Quellen und Nachweise

ORD-Eintrag
ord-b943c0d410744239aaebae8c2953c235
Quelldatensatz
uspto-grants-1981_07
Patentnummer
US04279904

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