Sodium Hydroxide → 4-[(1-Methylpyrrolidin-2-yl)methyl]aniline

HRID 1278083Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1278083
[NH2:1][C:2]1[CH:15]=[CH:14][C:5]([CH2:6][CH:7]2[N:11]([CH3:12])[C:10](=O)[CH2:9][CH2:8]2)=[CH:4][CH:3]=1.[H-].[Al+3].[Li+].[H-].[H-].[H-].[OH-].[Na+]>O1CCCC1>[NH2:1][C:2]1[CH:15]=[CH:14][C:5]([CH2:6][CH:7]2[CH2:8][CH2:9][CH2:10][N:11]2[CH3:12])=[CH:4][CH:3]=1

Komponenten

5

Edukt 3

HCID 14798Sodium HydroxideHCID 21226445Aluminium lithium hydrideHCID 234525985-(4-Aminobenzyl)-1-methylpyrrolidin-2-one

Produkt 1

HCID 131869044-[(1-Methylpyrrolidin-2-yl)methyl]aniline

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 8028TetrahydrofuranLösungsmittel

Versuchsvorschrift

Boil 2.04 g of 5-(4-aminobenzyl)-1-methylpyrrolidin-2-one and 0.7 g of lithium aluminum hydride under reflux for 20 hours in 20 ml of tetrahydrofuran. Decompose the resulting reaction product by admixing it with ice water. After adding 10 ml of 6 N sodium hydroxide solution to the decomposed product, extract it with diethyl ether. Dry the ether extract over sodium sulfate and concentrate it to obtain the title compound in free-base form. Convert the thus-obtained base into the dihydrochloride [m.p. (from methanol/ether)>242° (decomp.)] with methanol/ethereal hydrochloric acid.

Aufarbeitung

  1. customthe resulting reaction product
  2. extractionextract it with diethyl ether
  3. dry with materialDry the ether
  4. extractionextract over sodium sulfate
  5. concentrationconcentrate it

Quellen und Nachweise

ORD-Eintrag
ord-9ce85bc1244541b58f3a82f1a9a0411a
Quelldatensatz
uspto-grants-1981_07
Patentnummer
US04279918

Notizen zur Reaktion

Wird geladen…