2-Amino-5-bromopyridine → 1-(2-Chloro-6-fluorobenzoyl)-3-(5-bromo-2-pyridinyl)urea

HRID 1278187Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1278187
[Cl:1][C:2]1[CH:22]=[CH:21][CH:20]=[C:19]([F:23])[C:3]=1[C:4]([NH:6][C:7]([O:9]C1C=CC([N+]([O-])=O)=CC=1)=O)=[O:5].[Br:24][C:25]1[CH:26]=[CH:27][C:28]([NH2:31])=[N:29][CH:30]=1>>[Cl:1][C:2]1[CH:22]=[CH:21][CH:20]=[C:19]([F:23])[C:3]=1[C:4]([NH:6][C:7]([NH:31][C:28]1[CH:27]=[CH:26][C:25]([Br:24])=[CH:30][N:29]=1)=[O:9])=[O:5]

Komponenten

3

Edukt 2

HCID 706222-Amino-5-bromopyridineHCID 570409802-Chloro-6-fluorobenzamidocarboxylic acid, 4-nitrophenyl ester

Produkt 1

HCID 130230741-(2-Chloro-6-fluorobenzoyl)-3-(5-bromo-2-pyridinyl)urea

Versuchsvorschrift

To a solution of 2-chloro-6-fluorobenzamidocarboxylic acid, 4-nitrophenyl ester, in an inert organic solvent is added 5-bromo-2-aminopyridine. The reaction mixture is stirred at an elevated temperature for a period of time, and is then evaporated to dryness under vacuum. The product named in the heading above, identical to the product of Example 2, is isolated and purified by recrystallization.

Aufarbeitung

  1. customis then evaporated to dryness under vacuum
  2. customis isolated
  3. custompurified by recrystallization

Quellen und Nachweise

ORD-Eintrag
ord-f41619048b9f44fe984c3c1b1e1bfa8c
Quelldatensatz
uspto-grants-1981_07
Patentnummer
US04281003

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