2-Amino-5-chloropyridine → Benzamide, 2-chloro-N-(((5-chloro-2-pyridinyl)amino)carbonyl)-6-fluoro-

HRID 1278188Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1278188
[Cl:1][C:2]1[CH:22]=[CH:21][CH:20]=[C:19]([F:23])[C:3]=1[C:4]([NH:6][C:7]([O:9]C1C=CC([N+]([O-])=O)=CC=1)=O)=[O:5].[Cl:24][C:25]1[CH:26]=[CH:27][C:28]([NH2:31])=[N:29][CH:30]=1>>[Cl:1][C:2]1[CH:22]=[CH:21][CH:20]=[C:19]([F:23])[C:3]=1[C:4]([NH:6][C:7]([NH:31][C:28]1[CH:27]=[CH:26][C:25]([Cl:24])=[CH:30][N:29]=1)=[O:9])=[O:5]

Komponenten

3

Edukt 2

HCID 661742-Amino-5-chloropyridineHCID 570409802-Chloro-6-fluorobenzamidocarboxylic acid, 4-nitrophenyl ester

Produkt 1

HCID 174171Benzamide, 2-chloro-N-(((5-chloro-2-pyridinyl)amino)carbonyl)-6-fluoro-

Versuchsvorschrift

A portion of 2-chloro-6-fluorobenzamidocarboxylic acid, 4-nitrophenyl ester, is combined with a portion of 5-chloro-2-aminopyridine in an inert organic solvent. The reaction mixture is stirred at elevated temperature for a period of time, and is then evaporated under vacuum. The product named in the heading above, identical to the product of Example 3, is isolated by recrystallization.

Aufarbeitung

  1. customis then evaporated under vacuum
  2. customis isolated by recrystallization

Quellen und Nachweise

ORD-Eintrag
ord-e096d2173e2a4fe79dd218b57d9a5401
Quelldatensatz
uspto-grants-1981_07
Patentnummer
US04281003

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