2-Amino-5-(trifluoromethyl)pyridine → 1-(2-Chloro-6-fluorobenzoyl)-3-(5-trifluoromethyl-2-pyridinyl)urea

HRID 1278189Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1278189
[Cl:1][C:2]1[CH:22]=[CH:21][CH:20]=[C:19]([F:23])[C:3]=1[C:4]([NH:6][C:7]([O:9]C1C=CC([N+]([O-])=O)=CC=1)=O)=[O:5].[F:24][C:25]([F:34])([F:33])[C:26]1[CH:27]=[CH:28][C:29]([NH2:32])=[N:30][CH:31]=1>>[Cl:1][C:2]1[CH:22]=[CH:21][CH:20]=[C:19]([F:23])[C:3]=1[C:4]([NH:6][C:7]([NH:32][C:29]1[CH:28]=[CH:27][C:26]([C:25]([F:33])([F:24])[F:34])=[CH:31][N:30]=1)=[O:9])=[O:5]

Komponenten

3

Edukt 2

HCID 7358622-Amino-5-(trifluoromethyl)pyridineHCID 570409802-Chloro-6-fluorobenzamidocarboxylic acid, 4-nitrophenyl ester

Produkt 1

HCID 205331381-(2-Chloro-6-fluorobenzoyl)-3-(5-trifluoromethyl-2-pyridinyl)urea

Versuchsvorschrift

A solution is made in an inert organic solvent of 2-chloro-6-fluorobenzamidocarboxylic acid, 4-nitrophenyl ester, and 5-trifluoromethyl-2-aminopyridine. The temperature of the reaction mixture is raised, and the mixture is stirred for a period of time. The mixture is then evaporated under vacuum, and the product named in the heading above, identical to the product of Example 4, is isolated and purified by recrystallization.

Aufarbeitung

  1. temperatureThe temperature of the reaction mixture is raised
  2. customThe mixture is then evaporated under vacuum
  3. customis isolated
  4. custompurified by recrystallization

Quellen und Nachweise

ORD-Eintrag
ord-77d0287908d94600903deb953a7eed4c
Quelldatensatz
uspto-grants-1981_07
Patentnummer
US04281003

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