N-bromobutanimide → HCID 12766251, Verbindung

HRID 1278214Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1278214
[N:1]1[CH:6]=[CH:5][CH:4]=[C:3]([C:7]2[N:12]3[N:13]=[CH:14][CH:15]=[C:11]3[N:10]=[CH:9][CH:8]=2)[CH:2]=1.[Br:16]N1C(=O)CCC1=O>ClCCl>[Br:16][C:15]1[CH:14]=[N:13][N:12]2[C:7]([C:3]3[CH:2]=[N:1][CH:6]=[CH:5][CH:4]=3)=[CH:8][CH:9]=[N:10][C:11]=12

Komponenten

4

Edukt 2

HCID 67184N-bromobutanimideHCID 11206374HCID 11206374, Verbindung

Produkt 1

HCID 12766251HCID 12766251, Verbindung

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 6344DichloromethaneLösungsmittel

Versuchsvorschrift

A mixture of 1.96 g. of 7-(3-pyridyl)pyrazolo[1,5-a]-pyrimidine and 1.97 g. of N-bromosuccinimide in 100 ml. of dichloromethane is heated on a steam bath for 15 minutes. The mixture is poured into ice cold 2.5 N sodium hydroxide. The organic layer is separated and dried then is passed through a column of hydrous magnesium silicate. The column is washed with dichloromethane and the eluent is concentrated and diluted with hexane to give 1.8 g. of the product of the example, m.p. 243°-244° C.

Aufarbeitung

  1. additionA mixture of 1.96 g
  2. customThe organic layer is separated
  3. customdried
  4. washThe column is washed with dichloromethane
  5. concentrationthe eluent is concentrated
  6. additiondiluted with hexane
  7. customto give 1.8 g

Quellen und Nachweise

ORD-Eintrag
ord-4c3bbabffed84782b30cb09ae69a4eaf
Quelldatensatz
uspto-grants-1981_07
Patentnummer
US04281000

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