Hydrochloric Acid → HCID 21163085, Verbindung

HRID 1278220Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1278220
[N:1]1[CH:6]=[CH:5][CH:4]=[C:3]([C:7]2[N:12]3[N:13]=[CH:14][C:15]([CH2:16][OH:17])=[C:11]3[N:10]=[CH:9][CH:8]=2)[CH:2]=1.Cl.[CH3:19]O>>[CH3:19][O:17][CH2:16][C:15]1[CH:14]=[N:13][N:12]2[C:7]([C:3]3[CH:2]=[N:1][CH:6]=[CH:5][CH:4]=3)=[CH:8][CH:9]=[N:10][C:11]=12

Komponenten

4

Edukt 3

HCID 313Hydrochloric AcidHCID 887Methanol2×HCID 21163070HCID 21163070, Verbindung

Produkt 1

HCID 21163085HCID 21163085, Verbindung

Versuchsvorschrift

To a mixture of 0.01 mole of 7-(3-pyridyl)pyrazolo-[1,5-a]pyrimidine-3-methanol in 50 ml. of methanol is added anhydrous hydrochloric acid in 10 ml. of methanol. The mixture is heated on a steam bath for 3 hours and the solvent removed. The residue is partitioned between dichloromethane and aqueous sodium bicarbonate. The dichloromethane solution is dried over magnesium sulfate, concentrated and diluted with hexane to give the product of the example.

Aufarbeitung

  1. temperatureThe mixture is heated on a steam bath for 3 hours
  2. customthe solvent removed
  3. customThe residue is partitioned between dichloromethane and aqueous sodium bicarbonate
  4. dry with materialThe dichloromethane solution is dried over magnesium sulfate
  5. concentrationconcentrated
  6. additiondiluted with hexane
  7. customto give the product of the example

Quellen und Nachweise

ORD-Eintrag
ord-f5620bc89ecd4c4ab9827a403433e477
Quelldatensatz
uspto-grants-1981_07
Patentnummer
US04281000

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