Sodium Cyanide → 12-Hydroxydodecanenitrile

HRID 1278385Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1278385
Br[CH2:2][CH2:3][CH2:4][CH2:5][CH2:6][CH2:7][CH2:8][CH2:9][CH2:10][CH2:11][CH2:12][OH:13].[C-:14]#[N:15].[Na+]>CN(C)C=O>[OH:13][CH2:12][CH2:11][CH2:10][CH2:9][CH2:8][CH2:7][CH2:6][CH2:5][CH2:4][CH2:3][CH2:2][C:14]#[N:15]

Komponenten

4

Edukt 2

HCID 8929Sodium CyanideHCID 7416311-Bromo-1-undecanol

Produkt 1

HCID 1033034812-Hydroxydodecanenitrile

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 6228DimethylformamideLösungsmittel

Versuchsvorschrift

A solution 4.6 g. of 11-bromoundecanol and 1.6 g. of sodium cyanide in 40 ml. of dimethylformamide is heated at 80° C. for 18 hours, cooled, and poured into ice-water. The mixture is extracted with methylene chloride and the extract is dried over anhydrous magnesium sulfate. Evaporation of the solution affords 12-hydroxydodecanonitrile as a yellow oil.

Aufarbeitung

  1. temperaturecooled
  2. extractionThe mixture is extracted with methylene chloride
  3. dry with materialthe extract is dried over anhydrous magnesium sulfate
  4. customEvaporation of the solution

Quellen und Nachweise

ORD-Eintrag
ord-1d9be8fa42bd4aa28b64c51da6d1f1bc
Quelldatensatz
uspto-grants-1981_07
Patentnummer
US04281018

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