Dichloromethane → 8-Chloro-6-(2-fluorophenyl)-1-methyl-3-morpholino-4H-imidazo[1,5-a][1,4]benzodiazepine

HRID 127852

Reaktionsgleichung

Reaktionsgleichung von HRID 127852
[Cl:1][C:2]1[CH:3]=[CH:4][C:5]2[N:11]3[C:12]([CH3:21])=[N:13][C:14]([N:15]4[CH2:20][CH2:19][O:18][CH2:17][CH2:16]4)=[C:10]3[CH2:9][N+:8]([O-])=[C:7]([C:23]3[CH:28]=[CH:27][CH:26]=[CH:25][C:24]=3[F:29])[C:6]=2[CH:30]=1.Cl[Si](Cl)(Cl)[Si](Cl)(Cl)Cl.C(Cl)Cl>C1(C)C=CC=CC=1>[Cl:1][C:2]1[CH:3]=[CH:4][C:5]2[N:11]3[C:12]([CH3:21])=[N:13][C:14]([N:15]4[CH2:20][CH2:19][O:18][CH2:17][CH2:16]4)=[C:10]3[CH2:9][N:8]=[C:7]([C:23]3[CH:28]=[CH:27][CH:26]=[CH:25][C:24]=3[F:29])[C:6]=2[CH:30]=1

Komponenten

5

Edukt 3

HCID 6344DichloromethaneHCID 83497HexachlorodisilaneHCID 130469888-Chloro-6-(2-fluorophenyl)-1-methyl-3-morpholino-4H-imidazo[1,5-a][1,4]benzodiazepine 5-oxide

Produkt 1

HCID 130469898-Chloro-6-(2-fluorophenyl)-1-methyl-3-morpholino-4H-imidazo[1,5-a][1,4]benzodiazepine

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 1140TolueneLösungsmittel

Versuchsvorschrift

A mixture of 0.2 g of 8-chloro-6-(2-fluorophenyl)-1-methyl-3-morpholino-4H-imidazo[1,5-a][1,4]-benzodiazepine 5-oxide, 0.2 ml of hexachlorodisilane and 10 ml of methylene chloride was allowed to sit for two days. It was then diluted with toluene and washed with 1 N sodium hydroxide solution. The organic phase was dried and evaporated. Crystallization of the residue from ether/hexane gave end product with mp 172°-174° C.

Aufarbeitung

  1. washwashed with 1 N sodium hydroxide solution
  2. customThe organic phase was dried
  3. customevaporated
  4. customCrystallization of the residue from ether/hexane
  5. customgave end product with mp 172°-174° C.

Quellen und Nachweise

ORD-Eintrag
ord-5a616f272d9344a99ef7c04f1ad63fa5
Quelldatensatz
uspto-grants-1981_03
Patentnummer
US04257946

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